In this collaborative episode of “The Nucleus” by Regeneron, John Overton, PhD, Vice President and Chief Sequencing Officer at Regeneron Genetics Center (RGC), is joined by Jesse McQuarters, Editor at STAT Brand Studio, for an in-depth discussion exploring how integrating proteomics and multi-omics can deliver deeper insight into how diseases develop — and how science can better predict and prevent them. From vast global biobanks to cloud-powered analytics and next-generation assays, the episode unpacks how these rapidly expanding data ecosystems are revealing early biological signals, uncovering hidden risk factors, and helping researchers build a deeper, more connected picture of human biology.

The discussion also looks ahead to what it will take to bring proteomics into everyday healthcare—and how these insights could shift medicine from reactive to proactive. The conversation highlights emerging evidence that proteomic patterns can reveal risks for conditions like cardiovascular disease, liver inflammation, and even certain cancers long before symptoms appear, potentially replacing invasive procedures with simple blood tests. With a focus on global data collaborations, scalable technologies, and the growing role of AI, the episode paints a compelling vision of how multi-omics science could transform routine care and redefine how we detect, monitor, and prevent disease.