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Scientific Publications

Citizens of Science

In our quest to invent life-transforming medicines for people with serious diseases, we encourage our colleagues to publish their research in leading scientific journals.

The links on this page are not affiliated with Regeneron Pharmaceuticals, Inc. Links to sites outside of Regeneron are provided as a resource to the viewer. Regeneron accepts no responsibility for the content of linked sites.

Featured Publications
  • Early-Stage Research
  • Clinical Research
Cardiovascular & Renal
The Association between Factor XI Deficiency and the Risk of Bleeding, Cardiovascular, and Venous Thromboembolic Events

Published in Thromb Haemost. 2021 Sep 23. doi: 10.1055/s-0041-1735971. Online ahead of print.

Immunology & Inflammation
Development of Novel Glucocorticoids for Use in Antibody-Drug Conjugates for the Treatment of Inflammatory Diseases

Published in J Med Chem. 2021 Aug 11. doi: 10.1021/acs.jmedchem.1c00541. Online ahead of print.

Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes

Published in Commun Biol. 2021 Jul 26;4(1):913. doi: 10.1038/s42003-021-02438-x.

Obesity, Muscle & Metabolism
Five-in-One: Simultaneous isolation of multiple major liver cell types from livers of normal and NASH mice

Published in J Cell Mol Med. 2021 Sep 23. doi: 10.1111/jcmm.16933. Online ahead of print.

Oncology
Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

Published in Sci Rep. 2021 Jul 13;11(1):14397. doi: 10.1038/s41598-021-93842-0.

Preclinical PET imaging with the novel human antibody 89 Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues

Published in Journal for ImmunoTherapy of Cancer (2021) 9:1 Article Number: e002025. Date of Publication: 22 Jan 2021

Rare Diseases
Cell-type selective targeted delivery of a recombinant lysosomal enzyme for enzyme therapies

Published in Mol Ther. 2021 Aug 13:S1525-0016(21)00414-7. doi: 10.1016/j.ymthe.2021.08.020. Online ahead of print.

Site-Specific Quantitation of Drug Conjugations on Antibody-Drug Conjugates (ADCs) Using a Protease-Assisted Drug Deconjugation and Linker-like Labeling (PADDLL) Method

Published in Anal Chem. 2021 Jul 1. doi: 10.1021/acs.analchem.1c01619. Online ahead of print.

Host cell protein profiling of commercial therapeutic protein drugs as a benchmark for monoclonal antibody-based therapeutic protein development

Published in MAbs. 2021 Jan-Dec;13(1):1955811. doi: 10.1080/19420862.2021.1955811.

Liquid Chromatography-Multiple Reaction Monitoring-Mass Spectrometry Assay for Quantitative Measurement of Therapeutic Antibody Cocktail REGEN-COV Concentrations in COVID-19 Patient Serum

Published in Anal Chem. 2021 Sep 28;93(38):12889-12898. doi: 10.1021/acs.analchem.1c01613. Epub 2021 Aug 31.

General Medicine
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

Published in The New England journal of medicine (2021). Date of Publication: 26 Jun 2021

Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial

Published in Lancet Respir Med. 2021 Jul 21:S2213-2600(21)00167-3. doi: 10.1016/S2213-2600(21)00167-3. Online ahead of print.

REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19

Published in N Engl J Med. 2021 Sep 29. doi: 10.1056/NEJMoa2108163. Epub ahead of print

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19

Published in N Engl J Med. 2021 Aug 4. doi: 10.1056/NEJMoa2109682. Online ahead of print.

Baseline SARS-CoV-2 Viral Load is Associated With COVID-19 Disease Severity and Clinical Outcomes: Post-Hoc Analyses of a Phase 2/3 Trial

Published in J Infect Dis. 2021 Sep 8:jiab445. doi: 10.1093/infdis/jiab445. Online ahead of print.

Immunology & Inflammation
REGN1908-1909 monoclonal antibodies block Fel d 1 in cat allergic subjects: Translational pharmacokinetics and pharmacodynamics

Published in Clin Transl Sci. 2021 Aug 26. doi: 10.1111/cts.13112. Online ahead of print.

Pharmacokinetics and Pharmacodynamics of Itepekimab in Healthy Adults and Patients With Asthma: Phase I First-in-Human and First-in-Patient Trials

Published in Clin Transl Sci. 2021 Sep 15. doi: 10.1111/cts.13157. Online ahead of print.

Passive Prophylactic Administration with a Single Dose of Anti-Fel d 1 Monoclonal Antibodies REGN1908-1909 in Cat Allergen-Induced Allergic Rhinitis: A Randomized, Double-blind, Placebo Controlled Trial

Published in Am J Respir Crit Care Med. 2021 Mar 2. doi: 10.1164/rccm.202011-4107OC. Online ahead of print.

Infectious Diseases
Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV)

Published in The Journal of infectious diseases (2021). Date of Publication: 28 Jan 2021

Oncology
Integrated analysis of a phase 2 study of cemiplimab in advanced cutaneous squamous cell carcinoma: extended follow-up of outcomes and quality of life analysis

Published in J Immunother Cancer. 2021 Aug;9(8):e002757. doi: 10.1136/jitc-2021-002757.

Fixed Dose of Cemiplimab in Patients with Advanced Malignancies Based on Population Pharmacokinetic Analysis

Published in Adv Ther. 2021 Mar 25. doi: 10.1007/s12325-021-01638-5. Online ahead of print.

Ophthalmology
Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From the PANORAMA Randomized Clinical Trial

Published in JAMA Ophthalmol. 2021 Aug 5. doi: 10.1001/jamaophthalmol.2021.2809. Online ahead of print.

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