Citizens of Science
In our quest to invent life-transforming medicines for people with serious diseases, we encourage our colleagues to publish their research in leading scientific journals.
Featured Publications
- Early-Stage Research
- Clinical Research
Genetics
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity
Published in Science. 2021 Jul 2;373(6550):eabf8683. doi: 10.1126/science.abf8683.
Computationally efficient whole-genome regression for quantitative and binary traits
Published in Nat Genet. 2021 May 20. doi: 10.1038/s41588-021-00870-7. Online ahead of print.
Immunology & Inflammation
A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells
Published in Blood Advances (2021) 5:5 (1291-1304). Date of Publication: 9 Mar 2021
Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses
Published in Sci Immunol. 2021 Apr 9;6(58):eabg0117. doi: 10.1126/sciimmunol.abg0117
Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine
Published in Sci Immunol 10.1126/sciimmunol.aax1686
Infectious Diseases
SARS-CoV-2 spike therapeutic antibodies in the age of variants
Published in J Exp Med. 2021 May 3;218(5):e20210198. doi: 10.1084/jem.20210198.
Oncology
Preclinical PET imaging with the novel human antibody 89 Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues
Published in Journal for ImmunoTherapy of Cancer (2021) 9:1 Article Number: e002025. Date of Publication: 22 Jan 2021
Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlled trial
Published in Lancet. 2021 Feb 13;397(10274):592-604. doi: 10.1016/S0140-6736(21)00228-2.
Technology
A framework for highly multiplexed dextramer mapping and prediction of T cell receptor sequences to antigen specificity
Published in Sci Adv. 2021 May 14;7(20):eabf5835. doi: 10.1126/sciadv.abf5835. Print 2021 May.
Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice
Published in Nat Commun. 2021 May 13;12(1):2770. doi: 10.1038/s41467-021-22932-4.
Immunology & Inflammation
Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease
Published in Nat Immunol. 2021 Feb;22(2):128-139. doi: 10.1038/s41590-020-00830-z. Epub 2021 Jan 4.
Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial
Published in Lancet Oncol. 2021 May 14:S1470-2045(21)00126-1. doi: 10.1016/S1470-2045(21)00126-1. Online ahead of print.
Dupilumab efficacy in adolescents with uncontrolled, moderate-to-severe asthma: LIBERTY ASTHMA QUEST
Published in Allergy. 2021 Apr 27. doi: 10.1111/all.14872. Online ahead of print.
Passive Prophylactic Administration with a Single Dose of Anti-Fel d 1 Monoclonal Antibodies REGN1908-1909 in Cat Allergen-Induced Allergic Rhinitis: A Randomized, Double-blind, Placebo Controlled Trial
Published in Am J Respir Crit Care Med. 2021 Mar 2. doi: 10.1164/rccm.202011-4107OC. Online ahead of print.
Infectious Diseases
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19
Published in N Engl J Med. 2020 Dec 17. doi: 10.1056/NEJMoa2035002
The monoclonal antibody combination REGEN-COV protects against SARS- CoV-2 mutational escape in preclinical and human studies
Published in Cell (2021), doi: https://doi.org/10.1016/ j.cell.2021.06.002.
Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV)
Published in The Journal of infectious diseases (2021). Date of Publication: 28 Jan 2021