Scientific Publications Citizens of Science
In our quest to invent life-transforming medicines for people with serious diseases, we encourage our colleagues to publish their research in leading scientific journals.
Featured Publications
- Early-Stage Research
- Clinical Research
Genetics
Rare coding variants in CHRNB2 reduce the likelihood of smoking
Published in Nat Genet. 2023 Jun 12. doi: 10.1038/s41588-023-01417-8.
A large meta-analysis identifies genes associated with anterior uveitis
Published in Nature Communications (2023) 14:1 Article Number: 7300. Date of Publication: 1 Dec 2023
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
Published in Nat Commun. 2024 Jan 30;15(1):888. doi: 10.1038/s41467-024-44701-9.
Immunology & Inflammation
TRAPnSeq allows high-throughput profiling of antigen-specific antibody-secreting cells
Published in Cell Rep Methods. 2023 Jul 7;3(7):100522. doi: 10.1016/j.crmeth.2023.100522. eCollection 2023 Jul 24
A therapeutic strategy to target distinct sources of IgE and durably reverse allergy
Published in Sci Transl Med. 2023 Dec 13;15(726):eadf9561. doi: 10.1126/scitranslmed.adf9561. Epub 2023 Dec 13
Obesity, Muscle & Metabolism
A cellular and molecular spatial atlas of dystrophic muscle
Published in Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2221249120. doi: 10.1073/pnas.2221249120. Epub 2023 Jul 6
Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice
Published in Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2309967120. doi: 10.1073/pnas.2309967120. Epub 2023 Jul 31
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency
Published in Sci Transl Med. 2023 Nov 22;15(723):eadd4897. doi: 10.1126/scitranslmed.add4897. Epub 2023 Nov 22
Technology
Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM
Published in Nat Commun. 2023 Apr 26;14(1):2401. doi: 10.1038/s41467-023-37532-7
Aging
Effect of High-Dose Intravitreal Aflibercept, 8 mg, in Patients With Neovascular Age-Related Macular Degeneration: The Phase 2 CANDELA Randomized Clinical Trial
Published in JAMA Ophthalmol. 2023 Aug 3. doi: 10.1001/jamaophthalmol.2023.2421. Online ahead of print
General Medicine
Examining protective effects of SARS-CoV-2 neutralizing antibodies after vaccination or monoclonal antibody administration
Published in Nat Commun. 2023 Jun 17;14(1):3605. doi: 10.1038/s41467-023-39292-w
Effect of proprotein convertase subtilisin/kexin type 9 inhibition on cancer events: A pooled, post hoc, competing risk analysis of alirocumab clinical trials
Published in Cancer Med. 2023 Jul 17. doi: 10.1002/cam4.6310.
Immunology & Inflammation
Quality of life with cemiplimab plus chemotherapy for first-line treatment of advanced non-small cell lung cancer: Patient-reported outcomes from phase 3 EMPOWER-Lung 3
Published in Cancer. 2023 May 8. doi: 10.1002/cncr.34687
Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts
Published in N Engl J Med. 2023 May 21. doi: 10.1056/NEJMoa2303951
Efficacy and safety of dupilumab up to 52 weeks in adults and adolescents with eosinophilic oesophagitis (LIBERTY EoE TREET study): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial
Published in Lancet Gastroenterol Hepatol. 2023 Aug 31:S2468-1253(23)00204-2. doi: 10.1016/S2468-1253(23)00204-2.
Dupilumab for Eosinophilic Esophagitis in Patients 1 to 11 Years of Age
Published in N Engl J Med. 2024 Jun 27;390(24):2239-2251. doi: 10.1056/NEJMoa2312282.
Obesity, Muscle & Metabolism
Evinacumab for Pediatric Patients With Homozygous Familial Hypercholesterolemia
Published in Circulation. 2023 Oct 20. doi: 10.1161/CIRCULATIONAHA.123.065529. Online ahead of print