Citizens of Science
In our quest to invent life-transforming medicines for people with serious diseases, we encourage our colleagues to publish their research in leading scientific journals. This page is intended for U.S. audiences only.
Featured Publications
Aging
The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axisPublished in Cell Rep. 2025 Mar 6;44(3):115403. doi: 10.1016/j.celrep.2025.115403. Online ahead of print.
Single cell-resolved cellular, transcriptional, and epigenetic changes in mouse T cell populations linked to age-associated immune declinePublished in Proc Natl Acad Sci U S A. 2025 Apr 8;122(14):e2425992122. doi: 10.1073/pnas.2425992122. Epub 2025 Mar 31.
Genetics
A TMPRSS6-inhibiting mAb improves disease in a β-thalassemia mouse model and reduces iron in healthy humansPublished in JCI Insight. 2025 Jun 23;10(12):e191813. doi: 10.1172/jci.insight.191813. eCollection 2025 Jun 23.
A TMPRSS6-inhibiting mAb improves disease in a β-thalassemia mouse model and reduces iron in healthy humansPublished in JCI Insight. 2025 Jun 23;10(12):e191813. doi: 10.1172/jci.insight.191813. eCollection 2025 Jun 23.
Image guided construction of a common coordinate framework for spatial transcriptome dataPublished in Sci Rep. 2025 May 24;15(1):18074. doi: 10.1038/s41598-025-01862-x.
Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestriesPublished in Nat Commun. 2026 Feb 24;17(1):1654. doi: 10.1038/s41467-026-68825-2.
Immunology & Inflammation
Optimally engineered HLA/peptide-specific CAR-T cells outperform TCR-T cells to eradicate solid tumorsPublished in Sci Adv. 2026 Jan 23;12(4):eadx9371. doi: 10.1126/sciadv.adx9371. Epub 2026 Jan 21.
IL-33 expands plasma cells, disrupts germinal centers, and increases autoantibody production in micePublished in Nat Commun. 2025 Dec 23. doi: 10.1038/s41467-025-67867-2. Online ahead of print.
Infectious Diseases
Scalable Production of Recombinant Vesicular Stomatitis Virus Pseudoparticles Using HEK293 Suspension CulturesPublished in Biotechnol Bioeng. 2025 Jun 4. doi: 10.1002/bit.29042. Online ahead of print.
Obesity, Muscle & Metabolism
Hepatic PKA Mediates the Liver and Pancreatic Alpha-Cell CrosstalkPublished in Diabetes. 2025 Mar 17:db240958. doi: 10.2337/db24-0958. Online ahead of print.
GDF8 and activin A blockade protects against GLP-1-induced muscle loss while enhancing fat loss in obese male mice and non-human primatesPublished in Nat Commun. 2025 May 13;16(1):4377. doi: 10.1038/s41467-025-59485-9.
GDF8 and activin A blockade protects against GLP-1-induced muscle loss while enhancing fat loss in obese male mice and non-human primatesPublished in Nat Commun. 2025 May 13;16(1):4377. doi: 10.1038/s41467-025-59485-9.
Ophthalmology
Differential Analysis of Core Complement Components Expression and Localization Across Rodent, Non-Human Primate, and Human Ocular TissuesPublished in Exp Eye Res. 2025 May 24:110433. doi: 10.1016/j.exer.2025.110433. Online ahead of print.
Technology
Iodoacetyl Tandem Mass Tag-Based Site-Specific Free Thiol Analysis (TMT-SiFTA) of Monoclonal AntibodiesPublished in Anal Chem. 2025 Jun 24. doi: 10.1021/acs.analchem.5c02553. Online ahead of print.
Manufacturing Process Intensification of Adeno-Associated Viral Vectors Type-8 Using Weak Partitioning Chromatography With UV-Based Process Analytical Technology (PAT)Published in 2025 Jul 17. doi: 10.1002/bit.70021
Critical considerations in small-scale model selection for filter flush determination: A case study on polyethersulfone membrane filtersPublished in J Pharm Sci. 2025 Sep 19:103997. doi: 10.1016/j.xphs.2025.103997. Online ahead of print.
Genetics
Computationally efficient meta-analysis of gene-based tests using summary statistics in large-scale genetic studiesPublished in Nat Genet. 2025 Nov 12. doi: 10.1038/s41588-025-02390-0. Online ahead of print.
DB-OTO Gene Therapy for Inherited DeafnessPublished in N Engl J Med. 2025 Oct 12. doi: 10.1056/NEJMoa2400521. Online ahead of print.
Immunology & Inflammation
Cemiplimab monotherapy as first-line treatment of patients with brain metastases from advanced non-small cell lung cancer with programmed cell death-ligand 1 ≥50Published in Cancer. 2025 May 15;131(10):e35864. doi: 10.1002/cncr.35864.
Dupilumab efficacy in patients with type 2 asthma and early Feno level reductionsPublished in J Allergy Clin Immunol Glob. 2025 Apr 15;4(3):100474. doi: 10.1016/j.jacig.2025.100474. eCollection 2025 Aug.
Efficacy and safety of cemdisiran siRNA in myasthenia gravis (NIMBLE): a double-blind, randomised, placebo-controlled, phase 3 trialPublished in Lancet. 2026 Apr 21:S0140-6736(26)00690-2. doi: 10.1016/S0140-6736(26)00690-2. Online ahead of print.
Long-Term Safety and Efficacy of Dupilumab Treatment in Children Aged 6 Months to 5 Years with Severe Atopic DermatitisPublished in Paediatr Drugs. 2026 Apr 2. doi: 10.1007/s40272-026-00747-4. Online ahead of print.
Dupilumab versus omalizumab in patients with chronic rhinosinusitis with nasal polyps and coexisting asthma (EVEREST): a multicentre, randomised, double-blind, head-to-head phase 4 trialPublished in Lancet Respir Med. 2025 Sep 28:S2213-2600(25)00287-5. doi: 10.1016/S2213-2600(25)00287-5. Online ahead of print.
Obesity, Muscle & Metabolism
Long-term safety and effectiveness of evinacumab in people with homozygous familial hypercholesterolemia: a plain language summaryPublished in Future Cardiol. 2025 Jun 23:1-12. doi: 10.1080/14796678.2025.2513805. Online ahead of print.
GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trialPublished in Nat Commun. 2025 May 13;16(1):4376. doi: 10.1038/s41467-025-59380-3.
GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trialPublished in Nat Commun. 2025 May 13;16(1):4376. doi: 10.1038/s41467-025-59380-3.
Evinacumab with or without lipoprotein apheresis in homozygous familial hypercholesterolaemiaPublished in Eur J Prev Cardiol. 2026 Mar 27:zwag182. doi: 10.1093/eurjpc/zwag182. Online ahead of print.
Oncology
Cemiplimab plus peltopepimut-S vaccine in recurrent cervical cancer: A phase 2 clinical trialPublished in Gynecol Oncol. 2025 Mar 27;196:28-35. doi: 10.1016/j.ygyno.2025.03.019. Online ahead of print.
Health-Related Quality of Life With Odronextamab Monotherapy for Relapsed/Refractory Follicular Lymphoma in the ELM-2 StudyPublished in Clin Lymphoma Myeloma Leuk. 2025 May 23:S2152-2650(25)00182-X. doi: 10.1016/j.clml.2025.05.017. Online ahead of print.
Fianlimab, a human lymphocyte activation gene-3 monoclonal antibody, in combination with cemiplimab: Tumor-specific expansion cohorts in advanced malignanciesPublished in Cancer. 2026 May 1;132(9):e70396. doi: 10.1002/cncr.70396.
Review of patient-reported outcomes in EMPOWER-Lung 1 in patients with advanced non-small cell lung cancer treated with cemiplimab versus chemotherapyPublished in Cancer. 2026 Mar 15;132(6):e70339. doi: 10.1002/cncr.70339.
Early clearance of circulating tumor DNA and association with odronextamab response in relapsed/refractory FL and DLBCLPublished in Blood Adv. 2025 Sep 3:bloodadvances.2025016332. doi: 10.1182/bloodadvances.2025016332. Online ahead of print.
Ophthalmology
Clinical Outcomes in nAMD with Aflibercept 8 mg in the Phase 2 CANDELA StudyPublished in Ophthalmol Retina. 2025 Apr 1:S2468-6530(25)00152-6. doi: 10.1016/j.oret.2025.03.023. Online ahead of print.