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Scientific Publications

Citizens of Science

In our quest to invent life-transforming medicines for people with serious diseases, we encourage our colleagues to publish their research in leading scientific journals.

The links on this page are not affiliated with Regeneron Pharmaceuticals, Inc. Links to sites outside of Regeneron are provided as a resource to the viewer. Regeneron accepts no responsibility for the content of linked sites.

Featured Publications
  • Early-Stage Research
  • Clinical Research
Cardiovascular & Renal
Angiopoietin-like protein 3 (ANGPTL3) governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Published in J Lipid Res. 2020 Jul 9:jlr.RA120000888. doi: 10.1194/jlr.RA120000888. Online ahead of print.

Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5

Published in PLoS One 2020 May 8;15(5):e0231892 doi: 10 1371/journal pone 0231892 eCollection 2020

Genetics
Heterozygosity for a Pathogenic Variant in SLC12A3 That Causes Autosomal Recessive Gitelman Syndrome Is Associated with Lower Serum Potassium

Published in J Am Soc Nephrol. 2021 Mar;32(3):756-765. doi: 10.1681/ASN.2020071030. Epub 2021 Feb 4.

Infectious Diseases
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

Published in Science. 2020 Jun 15;eabd0827. doi: 10.1126/science.abd0827. Online ahead of print.

Oncology
Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlled trial

Published in Lancet. 2021 Feb 13;397(10274):592-604. doi: 10.1016/S0140-6736(21)00228-2.

A PSMA-targeting CD3 bispecific antibody induces antitumor responses that are enhanced by 4-1BB costimulation

Published in Cancer Immunol Res. 2020 Mar 17:canimm.0518.2019. doi: 10.1158/2326-6066.CIR-19-0518. Online ahead of print.

Ophthalmology
Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics

Published in Proc Natl Acad Sci U S A 2020 May 21:202001896 doi: 10 1073/pnas 2001896117 Online ahead of print

Cardiovascular & Renal
Evinacumab for Homozygous Familial Hypercholesterolemia

Published in N Engl J Med. 2020 Aug 20;383(8):711-720. doi: 10.1056/NEJMoa2004215.

Immunology & Inflammation
Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease

Published in Nat Immunol. 2021 Feb;22(2):128-139. doi: 10.1038/s41590-020-00830-z. Epub 2021 Jan 4.

Dupilumab treatment results in early and sustained improvements in itch in adolescents and adults with moderate-to-severe atopic dermatitis: analysis of the randomized phase 3 studies SOLO 1 & SOLO 2, AD ADOL, and CHRONOS

Published in J Am Acad Dermatol. 2020 Mar 2:S0190-9622(20)30305-4. doi: 10.1016/j.jaad.2020.02.060. Online ahead of print.

Infectious Diseases
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

Published in N Engl J Med. 2020 Dec 17. doi: 10.1056/NEJMoa2035002

Oncology
Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial

Published in Lancet Oncol. 2020 Feb;21(2):294-305. doi: 10.1016/S1470-2045(19)30728-4. Epub 2020 Jan 14.

Technology
Integration of liquid chromatography mass spectrometry with a heavy peptide response curve accurately measures unprocessed C-terminal lysine during peptide mapping analysis of therapeutic antibodies in a single run

Published in J Pharm Biomed Anal. 2021 Feb 12;197:113963. doi: 10.1016/j.jpba.2021.113963. Online ahead of print.

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