Scientific Publications

Citizens of Science

In our quest to invent life-transforming medicines for people with serious diseases, we encourage our colleagues to publish their research in leading scientific journals.

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Featured Publications
  • Early-Stage Research
  • Clinical Research
Cardiovascular & Renal
Angiopoietin-like protein 3 (ANGPTL3) governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Published in J Lipid Res. 2020 Jul 9:jlr.RA120000888. doi: 10.1194/jlr.RA120000888. Online ahead of print.

Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5

Published in PLoS One 2020 May 8;15(5):e0231892 doi: 10 1371/journal pone 0231892 eCollection 2020

Genetics
Heterozygosity for a Pathogenic Variant in SLC12A3 That Causes Autosomal Recessive Gitelman Syndrome Is Associated with Lower Serum Potassium

Published in J Am Soc Nephrol. 2021 Mar;32(3):756-765. doi: 10.1681/ASN.2020071030. Epub 2021 Feb 4.

Infectious Diseases
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

Published in Science. 2020 Jun 15;eabd0827. doi: 10.1126/science.abd0827. Online ahead of print.

Oncology
Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlled trial

Published in Lancet. 2021 Feb 13;397(10274):592-604. doi: 10.1016/S0140-6736(21)00228-2.

A PSMA-targeting CD3 bispecific antibody induces antitumor responses that are enhanced by 4-1BB costimulation

Published in Cancer Immunol Res. 2020 Mar 17:canimm.0518.2019. doi: 10.1158/2326-6066.CIR-19-0518. Online ahead of print.

Ophthalmology
Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics

Published in Proc Natl Acad Sci U S A 2020 May 21:202001896 doi: 10 1073/pnas 2001896117 Online ahead of print

Cardiovascular & Renal
Evinacumab for Homozygous Familial Hypercholesterolemia

Published in N Engl J Med. 2020 Aug 20;383(8):711-720. doi: 10.1056/NEJMoa2004215.

Immunology & Inflammation
Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease

Published in Nat Immunol. 2021 Feb;22(2):128-139. doi: 10.1038/s41590-020-00830-z. Epub 2021 Jan 4.

Dupilumab treatment results in early and sustained improvements in itch in adolescents and adults with moderate-to-severe atopic dermatitis: analysis of the randomized phase 3 studies SOLO 1 & SOLO 2, AD ADOL, and CHRONOS

Published in J Am Acad Dermatol. 2020 Mar 2:S0190-9622(20)30305-4. doi: 10.1016/j.jaad.2020.02.060. Online ahead of print.

Infectious Diseases
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

Published in N Engl J Med. 2020 Dec 17. doi: 10.1056/NEJMoa2035002

Oncology
Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial

Published in Lancet Oncol. 2020 Feb;21(2):294-305. doi: 10.1016/S1470-2045(19)30728-4. Epub 2020 Jan 14.

Technology
Integration of liquid chromatography mass spectrometry with a heavy peptide response curve accurately measures unprocessed C-terminal lysine during peptide mapping analysis of therapeutic antibodies in a single run

Published in J Pharm Biomed Anal. 2021 Feb 12;197:113963. doi: 10.1016/j.jpba.2021.113963. Online ahead of print.

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