Scientific Publications

Citizens of Science

In our quest to invent life-transforming medicines for people with serious diseases, we encourage our colleagues to publish their research in leading scientific journals.

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Featured Publications
  • Early-Stage Research
  • Clinical Research
Cardiovascular & Renal
The Association between Factor XI Deficiency and the Risk of Bleeding, Cardiovascular, and Venous Thromboembolic Events

Published in Thromb Haemost. 2021 Sep 23. doi: 10.1055/s-0041-1735971. Online ahead of print.

Immunology & Inflammation
Development of Novel Glucocorticoids for Use in Antibody-Drug Conjugates for the Treatment of Inflammatory Diseases

Published in J Med Chem. 2021 Aug 11. doi: 10.1021/acs.jmedchem.1c00541. Online ahead of print.

Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes

Published in Commun Biol. 2021 Jul 26;4(1):913. doi: 10.1038/s42003-021-02438-x.

Obesity, Muscle & Metabolism
Five-in-One: Simultaneous isolation of multiple major liver cell types from livers of normal and NASH mice

Published in J Cell Mol Med. 2021 Sep 23. doi: 10.1111/jcmm.16933. Online ahead of print.

Oncology
Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

Published in Sci Rep. 2021 Jul 13;11(1):14397. doi: 10.1038/s41598-021-93842-0.

Preclinical PET imaging with the novel human antibody 89 Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues

Published in Journal for ImmunoTherapy of Cancer (2021) 9:1 Article Number: e002025. Date of Publication: 22 Jan 2021

Rare Diseases
Cell-type selective targeted delivery of a recombinant lysosomal enzyme for enzyme therapies

Published in Mol Ther. 2021 Aug 13:S1525-0016(21)00414-7. doi: 10.1016/j.ymthe.2021.08.020. Online ahead of print.

Site-Specific Quantitation of Drug Conjugations on Antibody-Drug Conjugates (ADCs) Using a Protease-Assisted Drug Deconjugation and Linker-like Labeling (PADDLL) Method

Published in Anal Chem. 2021 Jul 1. doi: 10.1021/acs.analchem.1c01619. Online ahead of print.

Host cell protein profiling of commercial therapeutic protein drugs as a benchmark for monoclonal antibody-based therapeutic protein development

Published in MAbs. 2021 Jan-Dec;13(1):1955811. doi: 10.1080/19420862.2021.1955811.

Liquid Chromatography-Multiple Reaction Monitoring-Mass Spectrometry Assay for Quantitative Measurement of Therapeutic Antibody Cocktail REGEN-COV Concentrations in COVID-19 Patient Serum

Published in Anal Chem. 2021 Sep 28;93(38):12889-12898. doi: 10.1021/acs.analchem.1c01613. Epub 2021 Aug 31.

General Medicine
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

Published in The New England journal of medicine (2021). Date of Publication: 26 Jun 2021

Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial

Published in Lancet Respir Med. 2021 Jul 21:S2213-2600(21)00167-3. doi: 10.1016/S2213-2600(21)00167-3. Online ahead of print.

REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19

Published in N Engl J Med. 2021 Sep 29. doi: 10.1056/NEJMoa2108163. Epub ahead of print

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19

Published in N Engl J Med. 2021 Aug 4. doi: 10.1056/NEJMoa2109682. Online ahead of print.

Baseline SARS-CoV-2 Viral Load is Associated With COVID-19 Disease Severity and Clinical Outcomes: Post-Hoc Analyses of a Phase 2/3 Trial

Published in J Infect Dis. 2021 Sep 8:jiab445. doi: 10.1093/infdis/jiab445. Online ahead of print.

Immunology & Inflammation
REGN1908-1909 monoclonal antibodies block Fel d 1 in cat allergic subjects: Translational pharmacokinetics and pharmacodynamics

Published in Clin Transl Sci. 2021 Aug 26. doi: 10.1111/cts.13112. Online ahead of print.

Pharmacokinetics and Pharmacodynamics of Itepekimab in Healthy Adults and Patients With Asthma: Phase I First-in-Human and First-in-Patient Trials

Published in Clin Transl Sci. 2021 Sep 15. doi: 10.1111/cts.13157. Online ahead of print.

Passive Prophylactic Administration with a Single Dose of Anti-Fel d 1 Monoclonal Antibodies REGN1908-1909 in Cat Allergen-Induced Allergic Rhinitis: A Randomized, Double-blind, Placebo Controlled Trial

Published in Am J Respir Crit Care Med. 2021 Mar 2. doi: 10.1164/rccm.202011-4107OC. Online ahead of print.

Infectious Diseases
Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV)

Published in The Journal of infectious diseases (2021). Date of Publication: 28 Jan 2021

Oncology
Integrated analysis of a phase 2 study of cemiplimab in advanced cutaneous squamous cell carcinoma: extended follow-up of outcomes and quality of life analysis

Published in J Immunother Cancer. 2021 Aug;9(8):e002757. doi: 10.1136/jitc-2021-002757.

Fixed Dose of Cemiplimab in Patients with Advanced Malignancies Based on Population Pharmacokinetic Analysis

Published in Adv Ther. 2021 Mar 25. doi: 10.1007/s12325-021-01638-5. Online ahead of print.

Ophthalmology
Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From the PANORAMA Randomized Clinical Trial

Published in JAMA Ophthalmol. 2021 Aug 5. doi: 10.1001/jamaophthalmol.2021.2809. Online ahead of print.

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