Scientific Publications

Citizens of Science

In our quest to invent life-transforming medicines for people with serious diseases, we encourage our colleagues to publish their research in leading scientific journals.

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Featured Publications
  • Early-Stage Research
  • Clinical Research
The Activin/FLRG pathway associates with poor COVID-19 outcomes in hospitalized patients

Published in Mol Cell Biol. 2021 Nov 1:MCB0046721. doi: 10.1128/MCB.00467-21. Online ahead of print.

Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes

Published in Sci Rep. 2021 Nov 3;11(1):21565. doi: 10.1038/s41598-021-99091-5.

Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen

Published in Science. 2021 Dec 3;374(6572):1221-1227. doi: 10.1126/science.abe0348. Epub 2021 Dec 2.

Exome sequencing and analysis of 454,787 UK Biobank participants

Published in Nature. 2021 Oct 18. doi: 10.1038/s41586-021-04103-z. Online ahead of print.

Immunology & Inflamation
Humanization of T cell-mediated immunity in mice

Published in Sci Immunol. 2021 Dec 17;6(66):eabj4026. doi: 10.1126/sciimmunol.abj4026. Epub 2021 Dec 17.

Obesity, Muscle & Metabolism
Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity

Published in Cell Metab. 2021 Sep 23:S1550-4131(21)00422-8. doi: 10.1016/j.cmet.2021.09.003. Online ahead of print.

Identification of the specific causes of polysorbate 20 degradation in monoclonal antibody formulations containing multiple lipases

Published in Pharm Res. 2022 Jan 3. doi: 10.1007/s11095-021-03160-3. Online ahead of print.

High affinity human Fc specific monoclonal antibodies for capture kinetic analyses of antibody-antigen interactions

Published in Anal Biochem. 2021 Nov 14:114455. doi: 10.1016/j.ab.2021.114455. Online ahead of print.

AdRoit is an accurate and robust method to infer complex transcriptome composition

Published in Commun Biol. 2021 Oct 22;4(1):1218. doi: 10.1038/s42003-021-02739-1.

General Medicine
Compassionate Use of REGEN-COV ® in Patients with COVID-19 and Immunodeficiency-Associated Antibody Disorders

Published in Clin Infect Dis. 2021 Dec 31:ciab1059. doi: 10.1093/cid/ciab1059. Online ahead of print.

REGEN-COV(®) antibody cocktail bioanalytical strategy: comparison of LC-MRM-MS and immunoassay methods for drug quantification

Published in Bioanalysis. 2021 Dec;13(24):1827-1836. doi: 10.4155/bio-2021-0190. Epub 2021 Nov 8.

Population pharmacokinetics and exposure-response modeling for evinacumab in homozygous familial hypercholesterolemia

Published in CPT Pharmacometrics Syst Pharmacol. 2021 Sep 29. doi: 10.1002/psp4.12711. Online ahead of print.

Immunology & Inflamation
Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma

Published in N Engl J Med. 2021 Oct 28;385(18):1656-1668. doi: 10.1056/NEJMoa2024257.

Correlation of Change in Central Subfield Thickness and Change in Visual Acuity in Neovascular AMD: Post Hoc Analysis of VIEW 1 and 2

Published in Am J Ophthalmol. 2021 Nov 27:S0002-9394(21)00617-6. doi: 10.1016/j.ajo.2021.11.020. Online ahead of print.

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