Citizens of Science
In our quest to invent life-transforming medicines for people with serious diseases, we encourage our colleagues to publish their research in leading scientific journals. This page is intended for U.S. audiences only.
Featured Publications
Aging
Single cell-resolved cellular, transcriptional, and epigenetic changes in mouse T cell populations linked to age-associated immune declinePublished in Proc Natl Acad Sci U S A. 2025 Apr 8;122(14):e2425992122. doi: 10.1073/pnas.2425992122. Epub 2025 Mar 31.
Genetics
Metabolic Stability and Targeted Delivery of Oligonucleotides: Advancing RNA Therapeutics Beyond The LiverPublished in J Med Chem. 2025 Jan 8. doi: 10.1021/acs.jmedchem.4c02528. Online ahead of print.
A TMPRSS6-inhibiting mAb improves disease in a β-thalassemia mouse model and reduces iron in healthy humansPublished in JCI Insight. 2025 Jun 23;10(12):e191813. doi: 10.1172/jci.insight.191813. eCollection 2025 Jun 23.
Immunology & Inflammation
CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivoPublished in Sci Transl Med. 2025 Mar 26;17(791):eado9371. doi: 10.1126/scitranslmed.ado9371. Epub 2025 Mar 26.
The IL-4-IL-4Rα axis modulates olfactory neuroimmune signaling to induce loss of smellPublished in Allergy. 2024 Oct 17. doi: 10.1111/all.16338. Online ahead of print.
Infectious Diseases
Scalable Production of Recombinant Vesicular Stomatitis Virus Pseudoparticles Using HEK293 Suspension CulturesPublished in Biotechnol Bioeng. 2025 Jun 4. doi: 10.1002/bit.29042. Online ahead of print.
Monoclonal antibodies against the spike protein alter the endogenous humoral response to SARS-CoV-2 vaccination and infectionPublished in Sci Transl Med. 2024 Nov 6;16(772):eadn0396. doi: 10.1126/scitranslmed.adn0396. Epub 2024 Nov 6.
Obesity, Muscle & Metabolism
Hepatic PKA Mediates the Liver and Pancreatic Alpha-Cell CrosstalkPublished in Diabetes. 2025 Jun 1;74(6):885-897. doi: 10.2337/db24-0958
Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexesPublished in Nat Commun. 2024 Nov 12;15(1):9776. doi: 10.1038/s41467-024-54124-1.
GDF8 and activin A blockade protects against GLP-1-induced muscle loss while enhancing fat loss in obese male mice and non-human primatesPublished in Nat Commun. 2025 May 13;16(1):4377. doi: 10.1038/s41467-025-59485-9.
Ophthalmology
Differential Analysis of Core Complement Components Expression and Localization Across Rodent, Non-Human Primate, and Human Ocular TissuesPublished in Exp Eye Res. 2025 May 24:110433. doi: 10.1016/j.exer.2025.110433. Online ahead of print.
Technology
Iodoacetyl Tandem Mass Tag-Based Site-Specific Free Thiol Analysis (TMT-SiFTA) of Monoclonal AntibodiesPublished in Anal Chem. 2025 Jun 24. doi: 10.1021/acs.analchem.5c02553. Online ahead of print.
General Medicine
A phase III study to evaluate the long-term safety and efficacy of fasinumab in patients with pain due to osteoarthritis of the knee or hipPublished in Osteoarthr Cartil Open. 2024 Oct 22;6(4):100533. doi: 10.1016/j.ocarto.2024.100533. eCollection 2024 Dec.
Immunology & Inflammation
Cemiplimab monotherapy as first-line treatment of patients with brain metastases from advanced non-small cell lung cancer with programmed cell death-ligand 1 ≥50Published in Cancer. 2025 May 15;131(10):e35864. doi: 10.1002/cncr.35864.
Immunogenicity of dupilumab in adult and pediatric patients with atopic dermatitisPublished in Front Immunol. 2024 Nov 11;15:1466372. doi: 10.3389/fimmu.2024.1466372. eCollection 2024.
Dupilumab efficacy in patients with type 2 asthma and early Feno level reductionsPublished in J Allergy Clin Immunol Glob. 2025 Apr 15;4(3):100474. doi: 10.1016/j.jacig.2025.100474. eCollection 2025 Aug.
Infectious Diseases
Safety and Pharmacokinetics of Casirivimab and Imdevimab (CAS+IMD) in Pediatric Outpatients With COVID-19Published in J Pediatric Infect Dis Soc. 2024 Oct 1:piae105. doi: 10.1093/jpids/piae105. Online ahead of print.
Obesity, Muscle & Metabolism
Target-Mediated Modeling of Alirocumab in Adolescents and Children ≥8 to <12 Years of Age Using Phase II and III DataPublished in Clin Pharmacol Drug Dev. 2025 Mar 26. doi: 10.1002/cpdd.1523. Online ahead of print.
Population Pharmacokinetics and Exposure-Response Modeling for Evinacumab in Children, Adolescents, and Adults With Homozygous Familial HypercholesterolemiaPublished in CPT Pharmacometrics Syst Pharmacol. 2025 Mar 17. doi: 10.1002/psp4.70016. Online ahead of print.
Long-term safety and effectiveness of evinacumab in people with homozygous familial hypercholesterolemia: a plain language summaryPublished in Future Cardiol. 2025 Jun 23:1-12. doi: 10.1080/14796678.2025.2513805. Online ahead of print.
GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trialPublished in Nat Commun. 2025 May 13;16(1):4376. doi: 10.1038/s41467-025-59380-3.
Oncology
Cemiplimab plus peltopepimut-S vaccine in recurrent cervical cancer: A phase 2 clinical trialPublished in Gynecol Oncol. 2025 Mar 27;196:28-35. doi: 10.1016/j.ygyno.2025.03.019. Online ahead of print.
Health-Related Quality of Life With Odronextamab Monotherapy for Relapsed/Refractory Follicular Lymphoma in the ELM-2 StudyPublished in Clin Lymphoma Myeloma Leuk. 2025 May 23:S2152-2650(25)00182-X. doi: 10.1016/j.clml.2025.05.017. Online ahead of print.
Ophthalmology
Clinical Outcomes in nAMD with Aflibercept 8 mg in the Phase 2 CANDELA StudyPublished in Ophthalmol Retina. 2025 Apr 1:S2468-6530(25)00152-6. doi: 10.1016/j.oret.2025.03.023. Online ahead of print.
Rare Diseases
Comparison of PET/CT versus CT only in the assessment of new heterotopic ossification bone lesions in patients with fibrodysplasia ossificans progressivaPublished in Bone. 2024 Oct 10:117280. doi: 10.1016/j.bone.2024.117280. Online ahead of print.