INVESTIGATIONAL PIPELINE A POWERFUL RESEARCH AND DEVELOPMENT ENGINE

Explore Regeneron's clinical pipeline

Our pipeline is powered by end-to-end research and development capabilities. The Research team discovers promising new drug compounds. From there, the Global Development team brings these investigational candidates through the full clinical development process, from trial design to study execution and lifecycle management. Our product portfolio reflects the true collaborative spirit of Regeneron. This page is intended for U.S. residents only.

This graphic displays pipeline drug candidates currently undergoing clinical testing in a variety of diseases. The safety and efficacy of these drug candidates have not been fully evaluated by any regulatory authorities for the indications described in this section.

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Molecule Name

 

Therapeutic Area

Modality

Indication

Target

  •  
    27T51

    Therapeutic Area

    Oncology

    Modality

    Cell therapy

    Indication

    Ovarian cancer

    Target

    MUC16

  •  
    ALN-ANG3

    Therapeutic Area

    Cardiovascular/ Metabolic

    Modality

    Gene silencing

    Indication

    Healthy volunteers

    Target

    ANGPTL3

  •  
    ALN-PNP In collaboration with Alnylam

    Therapeutic Area

    Immunology & Inflammation

    Modality

    Gene silencing

    Indication

    Nonalcoholic steatohepatitis (NASH)

    Target

    PNPLA3

  •  
    ALN-SOD In collaboration with Alnylam

    Therapeutic Area

    Neurology

    Modality

    Gene silencing

    Indication

    SOD1 amyotrophic lateral sclerosis (ALS)

    Target

    SOD1

  •  
    Davutamig (REGN5093)

    Therapeutic Area

    Oncology

    Modality

    Bispecific antibodies

    Indication

    MET-altered advanced non-small cell lung cancer (NSCLC)

    Target

    Two distinct MET epitopes

  •  
    DB-OTO

    Therapeutic Area

    Rare Disease

    Modality

    Gene therapy

    Indication

    Hearing loss in pediatrics (Phase 1/2)

    Target

    AAV-based gene therapy

  •  
    DUPILUMAB/ LINVOSELTAMAB

    Therapeutic Area

    Immunology & Inflammation

    Modality

    Bispecific antibodies

    Monoclonal antibodies

    Indication

    Severe food allergy

    Target

    IL-4R/BCMA and CD3

  •  
    FIANLIMAB

    Therapeutic Area

    Oncology

    Hematology

    Modality

    Monoclonal antibodies

    Indication

    Solid tumors and advanced hematologic malignancies

    Target

    LAG-3

  •  
    LINVOSELTAMAB

    Therapeutic Area

    Hematology

    Modality

    Bispecific antibodies

    Indication

    Multiple myeloma

    Target

    BCMA and CD3

  •  
    "NEXT GENERATION" COVID ANTIBODY

    Therapeutic Area

    Infectious Disease

    Modality

    Monoclonal antibodies

    Indication

    Healthy volunteers

    Target

    SARS-CoV-2 variants

  •  
    Nezastomig (REGN5678)

    Therapeutic Area

    Oncology

    Modality

    Bispecific antibodies

    Indication

    Renal cell carcinoma

    Target

    PSMA and CD3

  •  
    Nezastomig (REGN5678) / REGN4336

    Therapeutic Area

    Oncology

    Modality

    Bispecific antibodies

    Indication

    Prostate cancer

    Target

    PSMA and CD28 / PSMA and CD3 combo

  •  
    NTLA-2001 In collaboration with Intellia

    Therapeutic Area

    Rare Disease

    Neurology

    Modality

    Gene editing

    Indication

    Transthyretin amyloidosis with Polyneuropathy (ATTR-PN)

    Target

    TTR gene knockout using CRISPR/Cas9

  •  
    ODRONEXTAMAB

    Therapeutic Area

    Oncology

    Hematology

    Modality

    Bispecific antibodies

    Indication

    Certain B-cell malignancies

    Target

    CD20 and CD3

  •  
    REGN13335

    Therapeutic Area

    Cardiovascular/ Metabolic

    Modality

    Monoclonal antibodies

    Indication

    Healthy volunteers

    Target

    PDGF-b antagonist

  •  
    REGN4336

    Therapeutic Area

    Oncology

    Modality

    Bispecific antibodies

    Indication

    Prostate cancer

    Target

    PSMA and CD3

  •  
    REGN5093-M114

    Therapeutic Area

    Oncology

    Modality

    Bispecific antibodies

    Indication

    MET overexpressing advanced cancer

    Target

    Two distinct MET epitopes

  •  
    REGN9035

    Therapeutic Area

    Cardiovascular/ Metabolic

    Modality

    Monoclonal antibodies

    Indication

    Reversal agent to REGN5381 in healthy volunteers

    Target

    NPR1

  •  
    Vonsetamig (REGN5459)

    Therapeutic Area

    Oncology

    Hematology

    Modality

    Bispecific antibodies

    Indication

    Transplant desensitization in patients with chronic kidney disease

    Target

    BCMA and CD3

  •  
    REGN5668

    Therapeutic Area

    Oncology

    Modality

    Bispecific antibodies

    Indication

    Platinum-resistant ovarian cancer

    Target

    MUC16 and CD28

  •  
    REGN5837

    Therapeutic Area

    Hematology

    Modality

    Bispecific antibodies

    Indication

    B-NHL

    Target

    CD22 and CD28

  •  
    REGN6569

    Therapeutic Area

    Oncology

    Modality

    Monoclonal antibodies

    Indication

    Solid tumors

    Target

    GITR

  •  
    REGN7544

    Therapeutic Area

    Cardiovascular/ Metabolic

    Modality

    Monoclonal antibodies

    Indication

    Healthy volunteers

    Target

    NPR1 antagonist

  •  
    REGN7999

    Therapeutic Area

    Hematology

    Modality

    Monoclonal antibodies

    Indication

    Transfusion dependent iron overload

    Target

    TMPRSS6

Molecule Name

 

Therapeutic Area

Modality

Indication

Target

  •  
    Rapirosiran (ALN-HSD)

    Therapeutic Area

    Immunology & Inflammation

    Modality

    Gene silencing

    Indication

    Nonalcoholic steatohepatitis (NASH)

    Target

    HSD17B13

  •  
    CEMIPLIMAB

    Therapeutic Area

    Oncology

    Modality

    Monoclonal antibodies

    Indication

    Neoadjuvant cutaneous squamous cell carcinoma (CSCC); First-line non-small cell lung cancer (NSCLC), BNT116 combination; Neoadjuvant hepatocellular carcinoma (HCC)

    Target

    PD-1

  •  
    DUPILUMAB In collaboration with Sanofi

    Therapeutic Area

    Immunology & Inflammation

    Modality

    Monoclonal antibodies

    Indication

    Ulcerative colitis; Eosinophilic gastroenteritis (Phase 2/3)

    Target

    IL-4R alpha subunit

  •  
    FIANLIMAB

    Therapeutic Area

    Oncology

    Modality

    Monoclonal antibodies

    Indication

    First-line advanced non-small cell lung cancer (NSCLC) (Phase 2/3); Perioperative NSCLC; Perioperative melanoma (Phase 2/3)

    Target

    LAG-3

  •  
    ITEPEKIMAB In collaboration with Sanofi

    Therapeutic Area

    Immunology & Inflammation

    Modality

    Monoclonal antibodies

    Indication

    Non-cystic fibrosis bronchiectasis (NCFB)

    Target

    IL-33

  •  
    LINVOSELTAMAB

    Therapeutic Area

    Oncology

    Hematology

    Modality

    Bispecific antibodies

    Indication

    Multiple myeloma (pivotal study); Earlier (pre-malignant) multiple myeloma; Monoclonal gammopathy of undetermined significance (MGUS); Light chain amyloidosis (ALA)

    Target

    BCMA and CD3

  •  
    MIBAVADEMAB

    Therapeutic Area

    Cardiovascular/ Metabolic

    Rare Disease

    Modality

    Monoclonal antibodies

    Indication

    Generalized lipodystrophy

    Target

    Leptin receptor (LEPR)

  •  
    Nezastomig (REGN5678)

    Therapeutic Area

    Oncology

    Modality

    Bispecific antibodies

    Indication

    Prostate cancer

    Target

    PSMA and CD28

  •  
    ODRONEXTAMAB

    Therapeutic Area

    Cardiovascular/ Metabolic

    Oncology

    Hematology

    Modality

    Bispecific antibodies

    Indication

    B-cell non-Hodgkin lymphoma (B-NHL) (pivotal study)

    Target

    CD20 and CD3

  •  
    REGN5381

    Therapeutic Area

    Cardiovascular/ Metabolic

    Modality

    Monoclonal antibodies

    Indication

    Heart failure

    Target

    NPR1

  •  
    REGN7075

    Therapeutic Area

    Oncology

    Modality

    Bispecific antibodies

    Indication

    Solid tumors

    Target

    EGFR and CD28

  •  
    REGN7257

    Therapeutic Area

    Hematology

    Modality

    Monoclonal antibodies

    Indication

    Aplastic anemia

    Target

    IL2Rg

  •  
    REGN7508

    Therapeutic Area

    Hematology

    Modality

    Monoclonal antibodies

    Indication

    Thrombosis

    Target

    Factor XI

  •  
    REGN9933

    Therapeutic Area

    Hematology

    Modality

    Monoclonal antibodies

    Indication

    Thrombosis

    Target

    Factor XI

  •  
    SARILUMAB In collaboration with Sanofi

    Therapeutic Area

    Immunology & Inflammation

    Modality

    Monoclonal antibodies

    Indication

    Systemic juvenile idiopathic arthritis (sJIA) (pivotal study)

    Target

    IL-6R

  •  
    Trevogrumab (REGN1033)

    Therapeutic Area

    Cardiovascular/ Metabolic

    Modality

    Monoclonal antibodies

    Indication

    Obesity

    Target

    Myostatin (GDF8)

  •  
    UBAMATAMAB (REGN4018)

    Therapeutic Area

    Oncology

    Modality

    Bispecific antibodies

    Indication

    Platinum-resistant ovarian cancer

    Target

    MUC16 and CD3

Molecule Name

 

Therapeutic Area

Modality

Indication

Target

  •  
    CEMIPLIMAB

    Therapeutic Area

    Oncology

    Modality

    Monoclonal antibodies

    Indication

    Adjuvant cutaneous squamous cell carcinoma (CSCC)

    Target

    PD-1

  •  
    DUPILUMAB In collaboration with Sanofi

    Therapeutic Area

    Immunology & Inflammation

    Modality

    Monoclonal antibodies

    Indication

    Asthma in pediatrics (2–5 years of age); bullous pemphigoid; chronic spontaneous urticaria (CSU); chronic pruritis of unknown origin

    Target

    IL-4R alpha subunit

  •  
    EYLEA HD (aflibercept) 8 mg In collaboration with Bayer

    Therapeutic Area

    Ophthalmology

    Modality

    Traps

    Indication

    Retinal vein occlusion (RVO)

    Target

    VEGF

  •  
    FIANLIMAB

    Therapeutic Area

    Oncology

    Modality

    Monoclonal antibodies

    Indication

    First-line metastatic melanoma; First-line adjuvant melanoma; First-line metastatic melanoma versus the combination of relatimab and nivolumab

    Target

    LAG-3

  •  
    GARETOSMAB

    Therapeutic Area

    Rare Disease

    Modality

    Monoclonal antibodies

    Indication

    Fibrodysplasia ossificans progressiva (FOP)

    Target

    Activin A

  •  
    ITEPEKIMAB In collaboration with Sanofi

    Therapeutic Area

    Immunology & Inflammation

    Modality

    Monoclonal antibodies

    Indication

    COPD

    Target

    IL-33

  •  
    LINVOSELTAMAB

    Therapeutic Area

    Hematology

    Modality

    Bispecific antibodies

    Indication

    Multiple myeloma

    Target

    BCMA and CD3

  •  
    NTLA-2001 In collaboration with Intellia

    Therapeutic Area

    Cardiovascular/ Metabolic

    Rare Disease

    Modality

    Gene editing

    Indication

    Transthyretin amyloidosis with cardiomyopathy (ATTR-CM)

    Target

    TTR gene knockout using CRISPR/Cas9

  •  
    ODRONEXTAMAB

    Therapeutic Area

    Hematology

    Modality

    Bispecific antibodies

    Indication

    Follicular lymphoma (FL); Diffuse large B-cell lymphoma (DLBCL)

    Target

    CD20 and CD3

  •  
    POZELIMAB (REGN3918)

    Therapeutic Area

    Ophthalmology

    Neurology

    Hematology

    Modality

    Monoclonal antibodies

    Gene silencing

    Indication

    Myasthenia gravis, cemdisiran combination; paroxysmal nocturnal hemoglobinuria (PNH), cemdisiran combination

    Target

    C5

  •  
    REGN5713-5714-5715

    Therapeutic Area

    Immunology & Inflammation

    Modality

    Monoclonal antibodies

    Indication

    Birch allergy

    Target

    Bet v 1

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