A POWERFUL RESEARCH AND
DEVELOPMENT ENGINE

Our unique ability to repeatedly and consistently translate science into medicine has led to a robust pipeline of clinical-stage medicines, all of which were discovered in our laboratories. Our investigational treatments target allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neuromuscular diseases, infectious diseases and rare diseases.

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Regeneron Pipeline: Phase 1 Medicines Regeneron Pipeline: Phase 1 Medicines
  • REGN6569
    GITR Antibody Solid tumors
  • ODRONEXTAMAB
    CD20 X CD3 Antibody B-cell malignancies
  • REGN4018*
    MUC16 X CD3 Antibody Platinum-resistant ovarian cancer
  • REGN5459*
    BCMA X CD3 Antibody Multiple myeloma
  • REGN5678
    PSMA X CD28 Antibody Prostate cancer
  • REGN5093
    MET X MET Antibody MET-altered advanced non-small cell lung cancer (NSCLC)
  • REGN7257
    IL2Rg Antibody Aplastic anemia
  • Casirivimab and imdevimab
    SARS-CoV-2 Virus Multi-Antibody Therapy Multi-dose safety study in healthy volunteers
  • REGN5381
    NPR1 Agonist Antibody Heart failure
  • REGN3767
    LAG-3 Antibody Solid tumors, advanced hematologic malignancies
  • REGN5668
    MUC16 x CD28 Antibody Ovarian cancer
  • REGN7075
    EGFR x CD28 Antibody Solid tumors
  • REGN6490
    IL-36R Antibody Palmoplantar pustulosis
  • ALN-HSD
    RNAi Nonalcoholic steatohepatitis
  • POZELIMAB + CEMDISIRAN
    C5 Antibody + C5 siRNA Therapeutic Paroxysmal nocturnal hemoglobinuria
  • NTLA-2001
    CRISPR-CAS-9 Hereditary transthyretin amyloidosis with polyneuropathy
Regeneron Pipeline: Phase 2 Medicines Regeneron Pipeline: Phase 2 Medicines
  • AFLIBERCEPT
    VEGF-Trap High-dose (8mg) for wet age-related macular degeneration (AMD)
  • CEMIPLIMAB*
    PD-1 Antibody Basal cell carcinoma (BCC), metastatic or locally advanced cutaneous squamous cell carcinoma (CSCC), neoadjuvant CSCC
  • ODRONEXTAMAB
    CD20 X CD3 Antibody B-cell non-Hodgkin lymphoma
  • REGN5458*
    BCMA X CD3 Antibody Multiple myeloma
  • SARILUMAB*
    IL-6R Antibody Polyarticular-course juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis
  • DUPILUMAB*
    IL-4R Antibody Peanut allergy, grass allergy
  • REGN1908-1909
    Fel d 1 Multi-Antibody Therapy Cat allergy
  • EVINACUMAB
    ANGPTL-3 Antibody Refractory hypercholesterolemia (both HeFH and non-FH), severe hypertriglyceridemia
  • REGN4461
    LEPR Agonist Antibody Generalized lipodystrophy
  • GARETOSMAB
    Activin-A Antibody Fibrodysplasia Ossificans Progressiva (FOP)
  • POZELIMAB
    C5 Antibody Paroxysmal nocturnal hemoglobinuria, CD-55 deficient protein-losing enteropathy
  • CEMDISIRAN
    C5 siRNA Therapeutic Immunoglobulin A nephropathy
  • Casirivimab and imdevimab
    SARS-CoV-2 Virus Multi-Antibody Therapy Multi-dose safety study in non-hospitalized patients
Regeneron Pipeline: Phase 3 Medicines Regeneron Pipeline: Phase 3 Medicines
  • AFLIBERCEPT
    VEGF-Trap Retinopathy of prematurity (ROP), high-dose formulation (8mg) for wet age-related macular degeneration (AMD) and diabetic macular edema (DME)
  • CEMIPLIMAB*
    PD-1 Antibody Non-small cell lung cancer (NSCLC), cervical cancer, adjuvant cutaneous squamous cell carcinoma (CSCC)
  • DUPILUMAB*
    IL-4R Antibody Atopic dermatitis in pediatric patients 6 mo.–5 y.o., asthma in pediatric patients 6-11 y.o., eosinophilic esophagitis in patients 6 and older, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, prurigo nodularis, chronic spontaneous urticaria, allergic bronchopulmonary aspergillosis, chronic inducible urticaria, chronic sinusitis without nasal polyposis, allergic fungal rhinosinusitis
  • Casirivimab and imdevimab
    SARS-CoV-2 Virus Multi-Antibody Therapy Treatment for certain hospitalized and non-hospitalized patients with COVID-19; prevention of COVID-19 in household contacts of diagnosed patients
  • ALIROCUMAB*
    PCSK9 Antibody Homozygous familial hypercholesterolemia (HoFH) in adults and pediatric patients, heterozygous familial hypercholesterolemia (HeFH) in pediatric patients
  • FASINUMAB
    NGF Antibody Osteoarthritis pain of the knee or hip
  • ITEPEKIMAB
    IL-33 Antibody Chronic obstructive pulmonary disease (COPD)
  • REGN5713-5714-5715
    Bet v 1 Antibodies Birch allergy

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* In collaboration with Sanofi

† In collaboration with Teva and Mitsubishi Tanabe

This graphic displays pipeline drug candidates currently undergoing clinical testing in a variety of diseases. The safety and efficacy of these drug candidates have not been fully evaluated by any regulatory authorities for the indications described in this section.