A POWERFUL RESEARCH AND
DEVELOPMENT ENGINE

Our unique ability to repeatedly and consistently translate science into medicine has led to a robust pipeline of clinical-stage medicines, all of which were discovered in our laboratories. Our investigational treatments target allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neuromuscular diseases, infectious diseases and rare diseases.

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Phase 1 trials Phase 1 trials
  • CEMIPLIMAB*
    PD-1 Antibody Cancer
  • REGN3767
    LAG-3 Antibody Cancer
  • REGN1979
    CD20xCD3 Antibody Cancer
  • REGN4018*
    MUC16xCD3 Antibody Cancer
  • REGN5093
    METxMET Antibody Cancer
  • REGN5458*
    BCMAxCD3 Antibody Cancer
  • REGN5459*
    BCMAxCD3 Antibody Cancer
  • REGN5678
    PSMAxCD28 Antibody Cancer
  • REGN5713-5714-5715
    Betv1 Antibody Birch Allergy
Phase 2 trials Phase 2 trials
  • AFLIBERCEPT
    VEGF Trap High-dose for wet age-related macular degeneration (AMD)
  • CEMIPLIMAB*
    PD-1 Antibody Basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (CSCC)
  • REGN1979
    CD20xCD3 Antibody Relapsed/refractory follicular lymphoma, non-Hodgkin lymphomas, diffuse large B-cell lymphoma
  • DUPILUMAB*
    IL-4R Antibody Grass allergy, peanut allergy
  • SARILUMAB*
    IL-6R Antibody Polyarticular-course juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis
  • REGN1908-1909
    Fel d 1 Antibody Cat allergy
  • REGN3500*
    IL-33 Antibody Asthma, chronic obstructive pulmonary disease (COPD), atopic dermatitis
  • REGN5069
    GFRα3 Antibody Osteoarthritis knee pain
  • REGN4461
    LEPR Antibody Generalized lipodystrophy
  • GARETOSMAB
    Activin A Antibody Fibrodysplasia Ossificans Progressiva (FOP)
  • EVINACUMAB
    ANGPTL-3 Antibody Refractory hypercholesterolemia (both HeFH and non-FH), severe hypertriglyceridemia
  • POZELIMAB
    C5 Antibody Paroxysmal nocturnal hemoglobinuria
Phase 3 trials Phase 3 trials
  • AFLIBERCEPT
    VEGF Trap Retinopathy of Prematurity (ROP)
  • ALIROCUMAB*
    PCSK9 Antibody Homozygous familial hypercholesterolemia (HoFH) in adults and pediatrics, heterozygous familial hypercholesterolemia in pediatrics
  • CEMIPLIMAB*
    PD-1 Antibody Non-small cell lung cancer (NSCLC), cervical cancer, cutaneous squamous cell carcinoma (CSCC) (adjuvant)
  • REGN-EB3
    Ebola Virus Antibody Ebola virus infection
  • DUPILUMAB*
    IL-4R Antibody Atopic dermatitis in pediatrics, asthma in pediatrics, eosinophilic esophagitis, chronic obstructive pulmonary disease (COPD), prurigo nodularis, bullous pemphigoid, chronic spontaneous urticaria
  • SARILUMAB*
    IL-6R Antibody Polymyalgia rheumatica, giant cell arteritis
  • EVINACUMAB
    ANGPTL-3 Antibody Homozygous familial hypercholesterolemia (HoFH)
  • FASINUMAB†
    NGF Antibody Chronic pain from osteoarthritis of the knee or hip

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* In collaboration with Sanofi

† In collaboration with Teva and Mitsubishi Tanabe

This graphic displays pipeline drug candidates currently undergoing clinical testing in a variety of diseases. The safety and efficacy of these drug candidates have not been fully evaluated by any regulatory authorities for the indications described in this section.