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2001 Publications

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.
Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, Yancopoulos GD.
Nature Cell Biol.
3(11):1014-9.
Angiogenesis during follicular development in the primate and its inhibition by treatment with truncated Flt-1-Fc (vascular endothelial growth factor Trap(A40))
Wulff C, Wiegand SJ, Saunders PT, Scobie GA, Fraser HM
Endocrinology.
142(7):3244-54
AXOKINE® Causes Significant Weight Loss in Severely and Morbidly Obese Subjects
Guler HP, Ettinger MP, Littlejohn TW, Schwartz SL, Weiss SL, Mcllwain HH, Heymsfield SB, Bray GA, Roberts WG, Acheson A, Heyman ER, Dark CL Vicary C
Intl J of Obesity and Rel Met Dis
25:S111, P291
Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2
Teichert-Kuliszewska K, Maisonpierre PC, Jones N, Campbell AI, Master Z, Bendeck MP, Alitalo K, Dumont DJ, Yancopoulos GD, Stewart DJ
Cardiovasc Res
49(3):659-70
Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity
Lambert PD, Anderson KD, Sleeman MW, Wong V, Tan J, Hijarunguru A, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ.
Proc Natl Acad Sci U S A
98(8):4652-7
DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells
Olaso E, Ikeda K, Eng FJ, Xu L, Wang LH, Lin HC, Friedman SL.
J Clin Invest
108(9):1369-78.
Direct cell adhesion to the angiopoietins mediated by integrins
Carlson TR, Feng Y, Maisonpierre PC, Mrksich M, Morla AO
J Biol Chem
276(28):26516-25
Disease Status and Use of Ventilatory Support by ALS Patients; ALS and other motor neuron disorders 2001
Cedarbaum, J.M. and Stambler, N.
Martin Dunitz Publishers, London, UK
1:1-4
Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control
Kullander K, Croll SD, Zimmer M, Pan L, McClain J, Hughes V, Zabski S, DeChiara TM, Klein R, Yancopoulos GD, Gale NW.
Genes Dev.
15(7):877-88
Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome.
Wong AK, Alfert M, Castrillon DH, Shen Q, Holash J, Yancopoulos GD, Chin L.
Proc Natl Acad Sci U S A.
98(13):7481-6.
Gene targeting in ES cells
DeChiara TM
Methods Mol Biol.
158:19-45
Gridlock in the blood.
Thurston G, Yancopoulos GD.
Nature.
414(6860):163-4
Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding
Marcelino J, Sciortino CM, Romero MF, Ulatowski LM, Ballock RT, Economides AN, Eimon PM, Harland RM, Warman ML
Proc Natl Acad Sci U S A
98(20):11353-8
Identification of ubiquitin ligases required for skeletal muscle atrophy
Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ
Science
294(5547):1704-8
Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus
Pencea V, Bingaman KD, Wiegand SJ, Luskin MB
J Neurosci.
21(17):6706-17
Luteal angiogenesis: prevention and intervention by treatment with vascular endothelial growth factor trap(A40)
Wulff C, Wilson H, Rudge JS, Wiegand SJ, Lunn SF, Fraser HM
J Clin Endocrinol Metab
86(7):3377-86
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulos GD, Glass DJ
Nat Cell Biol.
3(11):1009-13
Motoneuron survival is enhanced in the absence of neuromuscular junction formation in embryos
Terrado J, Burgess RW, DeChiara T, Yancopoulos G, Sanes JR, Kato AC.
J Neurosci.
21(9):3144-50.
Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression
MacQueen GM, Ramakrishnan K, Croll SD, Siuciak JA, Yu G, Young LT, Fahnestock M
Behav Neurosci
115(5):1145-53
Reduced Ia-afferent-mediated Hoffman reflex in streptozotocin-induced diabetic rats
Tonra JR, Cliffer KD, Carson SR, Lindsay RM, Bodine SC, DiStefano PS
Exp Neurol.
172(1):220-7
Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2 endothelial cells.
Zhang XQ, Takakura N, Oike Y, Inada T, Gale NW, Yancopoulos GD, Suda T.
Blood
98(4):1028-37
The bone morphogenetic proteins antagonist Noggin inhibits membranous ossification
Aspenberg P, Jeppsson C, Economides AN
J Bone Miner Res
16(3):497-500
The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism.
Labrador JP, Azcoitia V, Tuckermann J, Lin C, Olaso E, Manes S, Bruckner K, Goergen JL, Lemke G, Yancopoulos G, Angel P, Martinez C, Klein R.
EMBO Rep
2(5):446-52
Vascular growth factors in cerebral ischemia
Croll SD, Wiegand SJ
Mol Neurobiol.
23(2-3):121-35
VEGF-initiated blood-retinal barrier breakdown in early diabetes
Qaum T, Xu Q, Joussen AM, Clemens MW, Qin W, Miyamoto K, Hassessian H, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP.
Invest Ophthalmol Vis Sci
42(10):2408-13